abstract：:Powder filled sachets containing a 3:1 (w/w) powder mixture of diacetylmorphine base and caffeine anhydrate were developed as a dosage form for smokable heroin used for the treatment of chronic, treatment-resistant heroin addicts. The powder mixture was filled into sachets using a micro dose auger filler machine. The ...

journal_title：International journal of pharmaceutics

authors： Klous MG,Nuijen B,Van den Brink W,Van Ree JM,Beijnen JH

更新日期：2004-11-05 00:00:00

abstract：:Amorphous lactose will crystallise rapidly if its glass transition temperature is reduced below its storage temperature. This is readily achieved by storing samples at ambient temperature and a relative humidity (RH) of greater than 50%. If the sample is monitored in an isothermal microcalorimeter as it crystallises, ...

journal_title：International journal of pharmaceutics

authors： Dilworth SE,Buckton G,Gaisford S,Ramos R

更新日期：2004-10-13 00:00:00

abstract：:The aim of this study was to investigate the feasibility of the transdermal delivery of catechins and caffeine from green tea extract. Drug-in-adhesive patches containing 1.35, 1.03, 0.68, and 0.32 mg cm(-2) green tea extract were formulated and the dissolution of (-)-epigallocatechin gallate (EGCg), (-)-epigallocatec...

journal_title：International journal of pharmaceutics

authors： Batchelder RJ,Calder RJ,Thomas CP,Heard CM

更新日期：2004-09-28 00:00:00

abstract：:We present the design of an electronically controlled drug delivery system. The intravaginally located device is a low-invasive platform that can measure and react inside the cow vagina while providing external control and monitoring ability. The electronics manufactured from off the shelf components occupies 16 mL of...

journal_title：International journal of pharmaceutics

authors： Cross PS,Künnemeyer R,Bunt CR,Carnegie DA,Rathbone MJ

更新日期：2004-09-10 00:00:00

abstract：:Formulation of poorly water-soluble drugs in the most stable dosage form for oral delivery perhaps presents the greatest challenge to pharmaceutical industry. Physical transformation of drug substance into its more soluble but metastable amorphous form is one of the approaches for improving dissolution rate of such dr...

journal_title：International journal of pharmaceutics

authors： Ambike AA,Mahadik KR,Paradkar A

更新日期：2004-09-10 00:00:00

abstract：:Liposomes, coated with transferrin (Tf)-coupled polyethylene glycol are considered to be potent carriers for drug delivery to various organs via receptor-mediated endocytosis. Since Tf receptors were ubiquitously expressed in various organs, additional perturbation of the liposomes such as regulation of the size may b...

journal_title：International journal of pharmaceutics

authors： Hatakeyama H,Akita H,Maruyama K,Suhara T,Harashima H

更新日期：2004-08-20 00:00:00

abstract：:Cell-based and acute and subchronic in vivo toxicity profiles of a dendrimer based on melamine reveal that this class of molecules warrants additional study as vehicles for drug delivery. In cell culture, a substantial decrease in viability was observed at 0.1 mg/mL. For the acute studies, mice were administered 2.5, ...

journal_title：International journal of pharmaceutics

authors： Neerman MF,Zhang W,Parrish AR,Simanek EE

更新日期：2004-08-20 00:00:00

abstract：:To evaluate the intestinal permeability of poorly water-soluble compounds, it is of importance to completely dissolve them in a medium and to avoid precipitation during experiments. This study was undertaken to find an agent possessing a high-solubilizing capacity and exhibiting minimal modulating impact on membrane i...

journal_title：International journal of pharmaceutics

authors： Oda M,Saitoh H,Kobayashi M,Aungst BJ

更新日期：2004-08-06 00:00:00

abstract：:The purpose of this study was to determine quantitatively the amorphous fraction in crystalline-amorphous powder mixtures of trehalose, in order to assess the ability of the (13)C NMR technique for quantitative amorphous characterization. The NMR method is described in detail and its accuracy is compared to that of th...

journal_title：International journal of pharmaceutics

authors： Lefort R,De Gusseme A,Willart JF,Danède F,Descamps M

更新日期：2004-08-06 00:00:00

abstract：:Pellets coated with a new aqueous polyvinyl acetate dispersion, Kollicoat SR 30 D, could be compressed into tablets without rupture of the coating providing unchanged release profiles. In contrast, the compression of pellets coated with the ethylcellulose dispersion, Aquacoat ECD 30, resulted in rupture of the coating...

journal_title：International journal of pharmaceutics

authors： Dashevsky A,Kolter K,Bodmeier R

更新日期：2004-07-26 00:00:00

abstract：:This study explores the potential of DNA complexes prepared with methylated collagen (MC) and unmodified native collagen (NC) to deliver genes into cells. The physicochemical properties and transfection abilities of these two types of complexes are studied in parallel. MC was prepared by methylation of the carboxyl gr...

journal_title：International journal of pharmaceutics

authors： Wang J,Lee IL,Lim WS,Chia SM,Yu H,Leong KW,Mao HQ

更新日期：2004-07-26 00:00:00

abstract：:To optimize the in vivo ocular transfection efficiency of plasmid DNA (pDNA)/cationic liposome complexes, N-[1-(2,3-dioleyloxy)propyl]-N,N,N-trimethylammonium chloride (DOTMA)/dioleoylphosphatidylethanolamine (DOPE) (1:1 molar ratio) liposomes and DOTMA/cholesterol (Chol) (1:1 molar ratio) liposomes were prepared with...

journal_title：International journal of pharmaceutics

authors： Kawakami S,Harada A,Sakanaka K,Nishida K,Nakamura J,Sakaeda T,Ichikawa N,Nakashima M,Sasaki H

更新日期：2004-07-08 00:00:00

abstract：:D-glucosamine and chitosan were modified by the immobilization of thiol groups utilizing 2-iminothiolane. The toxicity profile of the resulting D-glucosamine-TBA (4-thiobutylamidine) conjugate, of chitosan-TBA conjugate and of the corresponding unmodified controls was evaluated in vitro. On the one hand, the cell memb...

journal_title：International journal of pharmaceutics

authors： Guggi D,Langoth N,Hoffer MH,Wirth M,Bernkop-Schnürch A

更新日期：2004-07-08 00:00:00

abstract：:This note describes a novel application of the food processing technology, known as high pressure processing (HPP), to the extraction of essential components of herbs. Herbal extracts may be used as drugs, as well as ingredients in food and cosmetics. We have run some pilot studies in our laboratories to demonstrate t...

journal_title：International journal of pharmaceutics

authors： Shouqin Z,Junjie Z,Changzhen W

更新日期：2004-07-08 00:00:00

abstract：:Solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC) are colloidal carrier systems providing controlled release profiles for many substances. Clotrimazole-loaded SLN and NLC were prepared by the hot high pressure homogenization technique in order to evaluate the physical stability of these particles...

journal_title：International journal of pharmaceutics

authors： Souto EB,Wissing SA,Barbosa CM,Müller RH

更新日期：2004-06-18 00:00:00

abstract：:Poly(methyl methacrylate) (PMMA) is used to fill the gap between the prosthesis and the surrounding bone in cemented arthroplasties. Biocompatibility problems related to bone cement application limit the clinical success of these cemented arthroplasties. Being the cement surface in close connection with the living bon...

journal_title：International journal of pharmaceutics

authors： Bettencourt A,Calado A,Amaral J,Alfaia A,Vale FM,Monteiro J,Montemor MF,Ferreira MG,Castro M

更新日期：2004-06-18 00:00:00

abstract：:The role of the newly discovered cysteine protease, cathepsin K, in osteoporosis and rheumatoid arthritis is reviewed. The current development of cathepsin K inhibitors and their targeted delivery using synthetic polymer carriers are discussed. Future challenges and possible strategies to improve these delivery system...

journal_title：International journal of pharmaceutics

authors： Wang D,Li W,Pechar M,Kopecková P,Brömme D,Kopecek J

更新日期：2004-06-11 00:00:00

abstract：:Bioadhesive buccal tablet formulations for delivery of nicotine into the oral cavity were developed. Carbomer (Carbopol)974P NF) (CP) and alginic acid sodium salt (NaAlg) were used as bioadhesive polymers in combination with hydroxypropyl methylcellulose (HPMC) at different ratios. Magnesium carbonate was incorporated...

journal_title：International journal of pharmaceutics

authors： Ikinci G,Senel S,Wilson CG,Sumnu M

更新日期：2004-06-11 00:00:00

abstract：:In attempts to avoid the systemic side effects of piroxicam (PC) (e.g. gastrotoxicity), several buccal gel formulations containing PC were prepared and their effects on the characteristics of the drug permeation through rabbit buccal mucosa in-vitro were evaluated using a Franz-type diffusion cell. The general rank or...

journal_title：International journal of pharmaceutics

authors： Attia MA,El-Gibaly I,Shaltout SE,Fetih GN

更新日期：2004-05-19 00:00:00

abstract：:Pharmaceutically usable microemulsion systems were prepared from water and isopropyl myristate with a constant amount of Tween 40 and Imwitor 308 at a mass ratio of 1. Their type and structure were examined by measuring density and surface tension, and by viscometry, electric conductivity, differential scanning calori...

journal_title：International journal of pharmaceutics

authors： Podlogar F,Gasperlin M,Tomsic M,Jamnik A,Rogac MB

更新日期：2004-05-19 00:00:00

abstract：:The purpose of this study was to improve the solubility and enhance the brain uptake of nimodipine (NM) in an o/w microemulsion, which was suitable for intranasal delivery. Three microemulsion systems stabilized by the nonionic surfactants either Cremophor RH 40 or Labrasol, and containing a variety of oils, namely is...

journal_title：International journal of pharmaceutics

authors： Zhang Q,Jiang X,Jiang W,Lu W,Su L,Shi Z

更新日期：2004-05-04 00:00:00

abstract：:The aim of this study was to establish a correlation between carrier characteristics and the dispersibility of drug from the blend. The influence of the roughness of a commonly used carrier material, lactose monohydrate, on the adhesion, dose uniformity, and aerodynamic properties of a model drug, terbutaline sulphate...

journal_title：International journal of pharmaceutics

authors： Flament MP,Leterme P,Gayot A

更新日期：2004-05-04 00:00:00

abstract：:The purpose of this study was to explore whether it is possible to use hyper differential scanning calorimetry (HDSC) to detect and quantify low levels of amorphous content in samples that are mostly crystalline. HDSC uses scan rates that are much faster than conventional DSC, and consequently results in greater sensi...

journal_title：International journal of pharmaceutics

authors： Saunders M,Podluii K,Shergill S,Buckton G,Royall P

更新日期：2004-04-15 00:00:00

abstract：:Local anaesthetics may be added to intravenous o/w emulsions of propofol to reduce the initial pain of injection. Due to incompatibility problems of the emulsion on the addition of a local anaesthetic solution, prior encapsulation of the drug within liposomes is suggested. The liposomes were prepared with the sonicati...

journal_title：International journal of pharmaceutics

authors： Müller M,Mackeben S,Müller-Goymann CC

更新日期：2004-04-15 00:00:00

abstract：:As none of the pharmacopoeial dissolution methods are suitable to evaluate the release rate of artemether and dihydroartemisinin from tablets, a 'two-phase partition-dissolution' method, based on the one of [J. Pharm. Sci. 85 (1996) 1060] was developed. It consists of an organic solvent in the upper part and the aqueo...

journal_title：International journal of pharmaceutics

authors： Gabriëls M,Plaizier-Vercammen J

更新日期：2004-04-15 00:00:00

abstract：:In this paper, we describe the haemolytic effect of parent para-sulphonato-calix-[n]-arenes and their derivatives bearing one pendant group at the lower rim of calix-arene towards human erythrocytes. A maximum of 30% of haemolysis has been observed for para-sulphonato-calix-[8]-arene for a concentration of 200 mM repr...

journal_title：International journal of pharmaceutics

authors： Da Silva E,Shahgaldian P,Coleman AW

更新日期：2004-04-01 00:00:00

abstract：:Fiber-optic near infrared (NIR) spectroscopy was used to investigate several key features of the polymorphic transitions observed during the crystallization and the filtration of SaC, an Active Pharmaceutical Ingredient (API) produced by Sanofi-Synthelabo. Using few samples, the spectroscopic data were calibrated to p...

journal_title：International journal of pharmaceutics

authors： Févotte G,Calas J,Puel F,Hoff C

更新日期：2004-04-01 00:00:00

abstract：:The model anti-inflammatory drug prednisolone (PS) was retained in chitosan (CS) gel beads, which were prepared in a 10% aqueous amino acid solution (pH 9.0). Sustained release of PS from the CS gel beads was observed. Carrageenan solution was injected into air pouches (AP), which were prepared subcutaneously on the d...

journal_title：International journal of pharmaceutics

authors： Kofuji K,Akamine H,Qian CJ,Watanabe K,Togan Y,Nishimura M,Sugiyama I,Murata Y,Kawashima S

更新日期：2004-03-19 00:00:00

abstract：:A well-balanced incubation saline is necessary for permeability experiments with the rat jejunal tissue in the diffusion chambers. At the same time the investigated substance must be chemically stable and sufficiently soluble in this incubation saline. To investigate whether the absence of some ions in incubation sali...

journal_title：International journal of pharmaceutics

authors： Zakelj S,Legen I,Veber M,Kristl A

更新日期：2004-03-19 00:00:00

abstract：:The redox chemistry and pharmacological studies of the novel blue ruthenium(III)-catecholamine complexes were investigated in aqueous medium and compared to the free catecholamines. The [Ru(III)(NH3)4(catecholamine)]+ can be oxidized or reduced reversibly in one electron redox couples in aqueous solution. This is in c...

journal_title：International journal of pharmaceutics

authors： de Lima RG,Marchesi MS,de Godoy MA,Cassano AO,de Oliveira AM,da Silva RS

更新日期：2004-03-01 00:00:00

abstract：UNLABELLED:To objectively evaluate the performance of new vaginal dosage forms, it is important to determine their time of residence and their distribution. This paper describes the in vivo characteristics of a reference and test product in this situation. METHOD:A randomised cross-over study was performed in the same...

journal_title：International journal of pharmaceutics

authors： Chatterton BE,Penglis S,Kovacs JC,Presnell B,Hunt B

更新日期：2004-03-01 00:00:00

abstract：:Gels formed in situ following oral administration of dilute aqueous solutions of pectin (1.0 and 1.5%, w/v) to rats were evaluated as vehicles for the sustained release of the expectorant drug ambroxol hydrochloride. The solutions contained calcium ions in complexed form, which on release in the acidic environment of ...

journal_title：International journal of pharmaceutics

authors： Kubo W,Miyazaki S,Dairaku M,Togashi M,Mikami R,Attwood D

更新日期：2004-03-01 00:00:00

abstract：:Thermoreversible nasal gels of Vitamin B(12) using pluronic PF 127 were aimed to improve absorption and patient compliance. In the present research work, effects of Vitamin B(12) and gel additives, viz. PF concentration, osmolarity, polyethylene glycol (PEG 15000) on thermodynamic properties of phase transitions at ge...

journal_title：International journal of pharmaceutics

authors： Pisal SS,Paradkar AR,Mahadik KR,Kadam SS

更新日期：2004-02-11 00:00:00

abstract：:A micro-capillary rheometer consisted of a fine needle with an internal diameter of 347 microm attached to a 1 ml removable-needle syringe within an Instron device that operated in compression mode to provide various crosshead speeds ranging from 150 to 950 mm min(-1) covering typical clinical injection rates, and tha...

journal_title：International journal of pharmaceutics

authors： Allahham A,Stewart P,Marriott J,Mainwaring DE

更新日期：2004-02-11 00:00:00

abstract：:Two different PLGA samples (Resomer 502 and Resomer 506), either alone or in combinations, were used to prepare microcapsules. Microcapsules were prepared using a double emulsion solvent evaporation technique. The efficiency of encapsulation increased significantly when a mixture of 1 part Resomer 506 and 7 parts Reso...

journal_title：International journal of pharmaceutics

authors： Graves RA,Pamujula S,Moiseyev R,Freeman T,Bostanian LA,Mandal TK

更新日期：2004-02-11 00:00:00

abstract：:The flow properties of pharmaceutical powders and blends used in solid oral dosage forms are an important consideration during dosage form development. The vibratory feeder method, a flow measurement technique that quantifies avalanche flow, has been adapted for measurement of the flow properties of common pharmaceuti...

journal_title：International journal of pharmaceutics

authors： Bhattachar SN,Hedden DB,Olsofsky AM,Qu X,Hsieh WY,Canter KG

更新日期：2004-01-28 00:00:00

abstract：:Substitutive hormonal therapies have to be administered for long periods. Thus, the development of sustained-release forms, as microparticle suspensions, is interesting in order to improve patient compliance by reducing dosing frequencies and side effects. The aim of this work was to compare different formulations of ...

journal_title：International journal of pharmaceutics

authors： Gibaud S,Jabir Al Awwadi N,Ducki C,Astier A

更新日期：2004-01-28 00:00:00

abstract：:Polyurethane polymers and poly(ether urethane) copolymers were chosen as drug carriers for alpha-tocopherol. This active ingredient is widely used as a strong antioxidant in many medical and cosmetic applications, but is rapidly degraded, because of its light, heat and oxygen sensitivity. Polyurethane and poly(ether u...

journal_title：International journal of pharmaceutics

authors： Bouchemal K,Briançon S,Perrier E,Fessi H,Bonnet I,Zydowicz N

更新日期：2004-01-09 00:00:00

abstract：:The synthesis and characterisation of semi-interpenetrating polymeric networks obtained by the radical-induced polymerisation of N-isopropylacrylamide in the presence of chitosan using tetraethyleneglycoldiacrylate as the crosslinker is described. The influence of the degree of crosslinking and that of the ratio of ch...

journal_title：International journal of pharmaceutics

authors： Verestiuc L,Ivanov C,Barbu E,Tsibouklis J

更新日期：2004-01-09 00:00:00

abstract：:The present investigation describes a procedure for the synthesis of a glycidyl methacrylated derivative from galactomannan, GA-MA, and the respective hydrogel formation. The galactomannan (GA), raw material, was purified and dissolved in DMSO. After dissolution, 4-dimethyl-amino-pyridine (DMAP) and glycidyl methacryl...

journal_title：International journal of pharmaceutics

authors： Reis AV,Cavalcanti OA,Rubira AF,Muniz EC

更新日期：2003-11-28 00:00:00